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Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

To make that happen, all you have to do is get enough healthy sleep from good sleep hygiene (more on that soon)

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It's much less likely to make you sleepy than other antihistamines

Or just marketing claims

Dietary and Lifestyle Considerations Include: Physical activity encourages return of venous blood from the legs back to the heart by activating the pumping action of the muscles