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In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of sodium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph compatible (i.e
Overall these results confirm that FOXO4-DRI promotes apoptosis in senescent endothelial cells by inhibiting FOXO4-P53 binding and phosphorylating P53
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doi:10.1002/jor.21107 Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D