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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis
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Understanding these differences helps clarify what to expect from each approach and why treatment timelines vary
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2017;546(7658):426-430.[DOI] 88
However, the long-range projection neurons that make up the bulk of these white matter pathways are the most vulnerable neurons during aging, and their deterioration can result in negative effects on the aforementioned cognitive processes (Mattson and Magnus, 2006)
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