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Temporary urine discoloration (bright yellow), which is harmless

Western Blot Total proteins were extracted in RIPA buffer (Sigma-Aldrich) that was supplemented with protease inhibitor cocktail (100 Sigma-Aldrich)

[DOI] [PMC free article] [PubMed] [Google Scholar] Sheikh M

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It's a less severe concern than, say, copper toxicity, but it's a practical safety issue that must be considered