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Mechanistically, honey enhances chemotherapeutic efficacy through multiple pathways: inhibition of drug efflux pumps (135), ROS-mediated apoptosis induction (136), and suppression of autophagy via AMPK/mTOR axis modulation (121)

Smoke is another exogenous source of AGE and it has in fact been seen that the serum levels of AGE in smokers are significantly higher compared to non-smokers [46]

Additionally, early research indicates it has antioxidant qualities

Certain antibiotics can cause drug-induced liver injury (DILI), though this is uncommon

Table 1 Antiretroviral drugs discussed in this review

This process is defined as active immunotherapy as the hosts immune system is either de novo activated or restimulated to mount an effective, tumor-specific immune reaction that may ultimately lead to tu-mor regression