For example, 72 weeks of treatment with tirzepatide in people with obesity (without diabetes, SURMOUNT-1 trial), resulted in an overall improvement of the total fat mass: total lean mass ratio, but there was a 10.9% reduction of total lean mass at the end of the study [22]
Abbreviations MTHFR: Methylenetetrahydrofolate reductase GSTO-1: Glutathione S-transferase omega-1 ROS: Reactive oxygen species DNA: Deoxyribonucleic acid HHcy: Hyperhomocysteinemia Hcy: Homocysteine TOAST: Trial of ORG 10172 in Acute Stroke Treatment PCR: Polymerase chain reaction HWE: Hardy-Weinberg equilibrium
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