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the effect involves tendon outgrowth, cell survival, and cell migration

[4] Higher thyroid antibody levels, particularly TPO antibodies, have been associated with an increased risk and severity of POI

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This also significantly elevated pro-inflammatory factors IL-6, TNF-, and IL-1 in the cerebrospinal fluid, and upregulated lipoxygenase (LOX), PTGS2, IL-6, and TNF- expression in microglial cells, which further promote inflammatory activation