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First, mechanistic studies should integrate single-cell spatial transcriptomics and mitochondrial metabolomics to map ferroptosis pathways in MSNs and microglia in the basal ganglia and striatum of patients with HD

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(PubMed) Paleologos M, Cumming RG, Lazarus R

Additionally, because of its high oxygen consumption, rich supply of polyunsaturated fatty acids, and exposure to visible light, the retina is particularly susceptible to oxidative stress caused by hyperglycemia [42]