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Updated April 2024

Recent elegant work has definitively identified that TP53 missense mutations in myeloid malignancies result in a dominant-negative effect without evidence of neomorphic gain-of-function activities, ultimately leading to a selection advantage when exposed to DNA damage.12 Thus, restoring wild-type function in TP53 mutant clones would be of profound beneficial impact

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Glutathione is the bodys most abundant intracellular antioxidant, playing a critical role in detoxification, immune function, and protection against oxidative stress

Peptides are short chains of amino acids (the building blocks of proteins), typically consisting of 250 amino acids

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