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Diabetes: Diabetes is associated with oxidative stress and inflammation, impacting the blood vessels throughout the body and the brain

Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output (Lee et al., 2010)

In the initial step of the lipid peroxidation process, bis-allylic hydrogens (H 2 C = CH 2 ) of unsaturated lipids (RH) react with hydroxyl radicals acting as promoters of radical chain reactions

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Typically self-limiting

However, there are multiple ways that cells can balance ROS and combat oxidative stress