BPC-157 also upregulates the phosphorylation level of extracellular signal-regulated kinases (ERK) 1 and 2, which are involved in cell growth and migration
A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, a TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration
KPV's smaller molecule size and more targeted mechanism may contribute to its cleaner anecdotal side effect profile, though long-term human data do not exist for either compound
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However, anecdotal evidence is inherently unreliable because users who take AOD 9604 are typically also dieting, exercising, and sometimes stacking it with other compounds
