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Similar to cagrilintide, pramlintide is primarily eliminated via the kidneys and, in a pharmacokinetic study in participants with type 1 diabetes, no statistically significant differences were noted in total (AUC 0- ) and peak ( C max ) exposure after administration of a single pramlintide 60 g dose in participants with mild, moderate or severe renal impairment compared with those with normal renal function, although inter-patient variability was high [20]

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Besides the (di)hydroxylation at positions 8, 9 or 10 of the proline ring, hydroxylation at the ergoline ring leading to 12-hydroxy-ergometrine was detected in rats after i.v

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