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17 It has become clear from studies with the purified enzyme that eNOS may become uncoupled in the absence of the NOS substrate L-arginine or the cofactor BH 4

It is primarily used to reduce systemic oxidative stress and support the health of the eyes and skin

The peptide suppresses pro-inflammatory cytokines including TNF-, IL-6, and TGF-, which are key drivers of chronic low-grade inflammation (inflammaging) in older skin

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10.1038/srep37246 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Pitt JM, Kroemer G, Zitvogel L