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A., Uelmen, J., Raether, J

Thus, there is not only a controversy between investigators who conclude that the sterile inflammatory response after APAP overdose is mainly involved in regeneration and those who believe that it aggravates the initial injury, but there are also extensive contradictions between reported results and suggested mechanisms among investigators who believe in an inflammatory injury component in APAP-induced hepatotoxicity

10.1136/thoraxjnl-2021-217576 Thorax

Similar content being viewed by others Introduction Biological thiols, including glutathione (GSH), cysteine (Cys) and homocysteine (Hcy), play a pivotal role in many biological processes such as regulating redox homeostasis, detoxification and metabolism and as an active site of enzymes and cofactors 1,2

Natural glutathione production declines with age (when you need it most), but you can increase glutathione levels through lifestyle choices

The review authors concluded that key questions around dosing, safety, and clinical outcomes remain unanswered