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Whether the added calcitonin-receptor component contributes anything to gastric motility specifically is not well characterized, and it is one of several places where cagrilintide cannot simply be treated as pramlintide that lasts a week. The kinetic transformation and the receptor-activity profile together mean that borrowing pramlintides gastric numbers is a working hypothesis, not a substitution of equals a theme that recurs throughout this analysis

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Annu Rev Pharmacol Toxicol 45:5188 Armstrong RN (1997) Structure, catalytic mechanism and evolution of the glutathione transferases

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