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In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes

399,400,401 Comparative analyses between OC tissues and normal tissues led to the identification of 14 differentially expressed genes related to disulfidptosis, which were used to create a risk signature

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Age Ageing 19:419424 Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Niemi M, Neuvonen PJ et al (2011) Pharmacokinetics of intravenous paracetamol in elderly patients