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Published mechanisms include upregulation of growth hormone receptor expression, promotion of angiogenesis via VEGF pathway activation, modulation of the nitric oxide system, and interaction with the dopaminergic and serotonergic systems in neurological models

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The most extensively studied is GHK-Cu (glycyl-L-histidyl-L-lysine copper), a tripeptide first isolated in 1973 by American biochemist Dr Loren Pickart

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