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Notably, most animal model acupuncture studies on TBI focused on regulating M1 phenotypic polarization

Among them, diacylglycerol activates PKC and impairs IRS-1 activation, while ceramides activate protein kinase C zeta (PKC) and protein phosphatase 2A (PP2A), resulting in dephosphorylation of Akt, 31,32 and promoting gluconeogenesis

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It has a critical role in protecting cells from oxidative stress and maintaining the immune system