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oral administration of a single dose of 3 grams of glutathione to health humans does not increase circulating glutathione to a clinically beneficial extent (Witschi et al., The Systemic Availability of Oral Glutathione, Eur

Acta Clin Belg 67, 190197

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Nrf2 knockdown prevents NFT-dependent increase in cellular glutathione levels To examine the correlation between Nrf2 activation and the increase in glutathione levels after NFT treatment, Nrf2 protein levels were experimentally lowered by siRNA-mediated knockdown, which was confirmed by Western blotting (Fig