Metformin attenuates Monosodium-Iodoacetate-Induced osteoarthritis via regulation of pain mediators and the Autophagy-Lysosomal pathway
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doi:10.1177/1756284820927306 43 Hildebrandt, W., Sauer, R., Bonaterra, G., Dugi, K
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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG