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The results of in vitro experiments are generally served for in vivo experiments, and two types of data need to be combined before used

Higher than normal levels of exposure to carcinogens have led IARC to classify certain occupations, such as firefighting and industrial painting, and work environments, such as iron and steel foundries or working around welding fumes, as class 1 carcinogens, meaning they are cancer-causing to humans

Welsh J, Palmer MB, Ajani JA, Liao Z, Swisher SG , Hofstetter WL, Allen PK, Settle SH, Gomez D, Likhacheva A, Cox JD, Komaki R

Hence, clinicians often face challenges in predicting the treatment response

Campbell JM et al

The original study that established disulfidptosis as a unique form of cell death driven by disulfide stress