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ConusPSeidmanLJFournierMXinLCleusixMBaumannPSet al

Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness

This is especially true in chronic pain conditions, where inflammation is often a downstream effect of deeper imbalance

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10.1089/scd.2013.0371 97 LiuT.ZhangL.JooD.SunS

Consequently, the NAD + /NADH imbalance propagates metabolic inflexibility, impairing neuron-glia metabolic crosstalk while dysregulating the -amino--carboxymuconate--semialdehyde decarboxylase (ACMSD)/kynurenine pathway, a critical alternate NAD + biosynthesis route [109, 110]