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Patients meeting the inclusion/exclusion criteria were randomized in a 2:1 ratio to receive a 2 mg dose of EGRIFTA (1 mg/vial formulation) or placebo subcutaneously daily for 26 weeks

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Pernicious anemia is a B12 deficiency anemia caused by the lack of intrinsic factor.[ref] What causes the lack of intrinsic factor in pernicious anemia

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In the Mthfr +/ and Mthfr / mice, the plasma total homocysteine levels were 1.6- and 10-fold higher, respectively, than the wildtype controls

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