In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12
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This is a commonly referenced study from 1963 claiming a half-life of 5-6 days: nature.com/articles/198200a0 Although I would not cite it as an authority, the six-day half-life has also made it onto the B12 page in Wikipedia, seemingly unchallenged
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Most patients treated with SKINVIVE injections notice results lasting six months, with some lasting nine or more months
The same 72-hour minimum spacing between doses applies