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Combining molecular oxygen reduction with energy generation during aerobic metabolism creates the potential of oxidative stress, i.e., damage to critical cellular macromolecules, which may lead to enzyme inactivation, lipid peroxidation, DNA damage, and ultimately, cell death (Regoli and Giuliani, 2014)
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In some embodiments, the otic formulation or composition comprises about 0.01% by weight of the viscosity modulating agent(s)
The claim appears to derive from theoretical extrapolation rather than experimental evidence