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Biomarkers for endothelial function, insulin sensitivity, intracellular signaling, maintaining DNA integrity , inflammation, metabolic flexibility, mitophagy (recycling old and damaged mitochondria) and cellular senescence (also called "zombie cells" as these cells have lost proper function, harm nearby cells and do not die off) are all favorably affected

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It adds a 13-amino-acid extension at the N-terminus and substitutes arginine for glutamic acid at position 3, which sharply reduces its binding to IGF binding proteins [1] [2]