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Comparing the binding modes of these natural inhibitors in hTYR and mTYR, it is evident that when searching for inhibitors for mTYR, smaller molecules or short peptides with elongated backbones are more desirable

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These tests need to be considered together and alongside clinical signs, history, physical exam findings, as well as the subjective clues that your veterinarian detects

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Often we choose V max values so that the steady state concentrations of substrates and products lie within the normal published ranges