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in addition, there is a clinical longitudinal study that is only used as evidence of correlation to support consistency, not causal inference

Abnormal HPA axis signaling can cause persistent cortisol increase, causing oxidative stress via many mechanisms, including mitochondrial dysfunction and endoplasmic reticulum stress (54)

Finally, SOD1 was found related to ALS, especially in the people of Asian region

Stroke 49 , 27522760 (2018)

Those with certain genetic traits might be more sensitive

It also can be concerning when youre already receiving treatment and then experience what appear to be worsening symptoms