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Retatrutide is a single-molecule triple hormone-receptor agonist that engages the GIP, GLP-1, and glucagon receptors at once

10.1073/pnas.2135113100 Proc

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The study reported higher mitochondrial membrane potential and increased mtDNA copy numbers in Epithalon-exposed oocytes

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In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls