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Several molecular mechanisms have been identified that may explain resistance and increased invasion after anti-angiogenic therapy in glioma, including mesenchymal transition of tumor cells, up-regulation of pro-angiogenic factors, activation of MET and up-regulation of MMPs [293,294,295,296]

doi: 10.1016/j.biomaterials.2010.09.057

As outcome, we computed the free energy surfaces and transition probabilities

Data availability Data is available from the authors upon reasonable request

Take your time, be meticulous, and follow the protocol

The Independent Assessor has indicated that unsatisfactory quarterly reports (also in non-payment times) may still have an effect on performance payments, depending on the severity of the assessed gaps