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Release 352 , 422437 (2022)

122 showed the difference between the pharmacokinetic profile in preterm babies and adults caused by immature liver and poor renal excretion and concluded that a 2-h infusion of 0.1 g/kg/h increased plasma melatonin from undetectable to approximately peak adult concentration

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Research has also shown that a genetic predisposition to accelerated tryptophan degradation can lead to increased tryptophan requirements in certain patients with sleep disorders

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