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doi:10.3389/fneur.2018.00178 Gurvich C, Maller JJ, Lithgow B, Haghgooie S, Kulkarni J

Pernicious anaemia can cause a wide range of symptoms, categorised into several groups

355 Trace metals toxic encephalopathies Contact with many metals, such as arsenic (As), manganese (Mn), mercury (Hg), lead (Pb), aluminium (Al), nickel (Ni), bismuth (Bi), cadmium (Cd), zinc (Zn), copper (Cu) and iron (Fe), may evoke acute or chronic toxic encephalopathies

Mller TD, et al

In the context of mutant p53 overexpression, which is often observed from pathogenic variants, the amount of APR-246 needed to restore the number of subunits necessary to overcome a dominant negative effect may very well surpass the threshold necessary to modulate the redox system

There is currently no cure, but symptoms can be significantly reduced and managed