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While myristoylation was demonstrated when a GCLC fragment was overexpressed [131], whether this actually occurs during apoptotic cell death remains unclear

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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)