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Although many ENS functions are independent of CNS input, the ENS does function as an interface to detect intestinal luminal cues that trigger upstream CNS signaling pathways

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This is the reason why different interventions such as probiotics, and dietary modifications intended to ameliorate the leaky gut, are suggested as potential treatments

Jun 2020;132(5):458-464

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Research Applications From Gut to Tendon Versatile Tissue Repair Research BPC-157 has demonstrated healing effects across remarkably diverse tissue types in preclinical models