Nature 475:471476
Specifically, the cells basal OCR, maximal OCR, and spare respiratory capacity were not impacted after 24 hours of incubation with 1 M CB-839 ( Supplemental Figure 6 )
Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology
Supplements that provide glutathione alone without vitamin C, alpha lipoic acid, or other supporting compounds rarely deliver optimal results
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