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Regarding the safety profile of autophagy activators in epilepsy, both lithium and rapamycin are not appropriate for long-term due to systemic adverse effects such as diabetes inspidus and bone marrow depression caused by lithium and rapamycin respectively (Livingstone and Rampes 2006

doi: 10.1016/j.sjbs.2021.10.021

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Palazzo M, Balsari A, Rossini A et al (2007) Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion