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Anti-diarrheal drugs may need to be prescribed to prevent this from occurring

This property has made oral administration a significant area of research to determine its bioavailability and systemic effects when ingested, which is why research-grade capsules are studied

Duration of Bioavailability : Due to its systemic distribution and role in cellular signaling, its effects are generally considered systemic and sustained

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Human clinical trials are limited, and optimal dosing, long-term safety, and comparative effectiveness with other therapies remain unclear

doi: 10.1038/s41598-019-40093-9