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A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]
doi:10.1016/j.jaci.2020.01.017
The main cause seems to be contractile activity that changes the redox state in muscles to a more oxidative state, reducing the NADH/NAD ratio in mitochondria [78]
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Olanzapine and its derivative, which showed even more potent anti-ferroptosis action, inhibited ferroptosis in mice HT22 hippocampal cells through trapping free radicals, exerting an antioxidant action [175]
According to a study by Chauhan et al., ashwagandha root extract powder effectively increases male libido in mature males with normal levels of prolactin and testosterone
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