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Hydrogen peroxide (H 2 O ) is needed as a substrate for this process

DeutzNEBauerJMBarazzoniRBioloGBoirieYBosy-WestphalAet al

These canonical functions positioned mGPDH as a redox-linked metabolic enzyme long before its recent recognition as a ferroptosis regulator via ubiquinol (CoQ 10 H 2 )-dependent antioxidant defense

Additionally, PFE avoids the risks associated with steroid injections and surgery, such as tissue damage or prolonged healing time

The in vitro antitumor capacity evaluation against HeLa cervical carcinoma indicated that they all displayed significant dose-related cancer-fighting properties, with BV/NFC nanoconjugates being the most efficient