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Enhancing the efficacy of glutamine metabolism inhibitors in cancer therapy

doi:10.1177/1178646920970902

Mutation of Cys-47 induces a positive cooperativity in glutathione transferase P1-1

When intestinal barrier integrity is compromised or permeability increases, LPS enters the circulation via the paracellular pathway or through lipoprotein-mediated transcellular transport

They measured the apparent levels of messenger RNA (mRNA) associated with urea cycle enzymes in the liver, evaluated the overall nitrogen balance, and hypothesized the nitrogen contents of various organs

Levels of intracellular cysteinylglycine and cysteine were not rescued by GSH supplementation in cystine-free conditions (Extended Data Fig