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2.2.1 Oxidative stress and mitochondrial dysfunction METH significantly increases the production of ROS and reactive nitrogen species, overwhelming antioxidant defenses in neurons

The biological rationale is interesting but unproven

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If you need to take pain-relieving medications long-term, discuss other treatment options to ease muscle spasms with your healthcare provider, such as: Topical pain relievers (creams and ointments) are less likely to cause systemic side effects compared to oral medications for pain relief Low-impact physical activities such as stretching, yoga, and tai chi Relaxation techniques Consult a healthcare provider before taking alternatives such as acetaminophen or other muscle relaxants, especially those with the following: A history of allergic reactions to ibuprofen or cyclobenzaprine

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