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Proximal tubule mTORC1 is a central player in the pathophysiology of diabetic nephropathy and its correction by SGLT2 inhibitors

Participants with renal impairment were recruited before those with normal renal function to help ensure similarity across groups in age and body weight

Two complementary lineagessystem Xc inhibitors and GPX4-directed agentsoffer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index

Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease