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Key takeaway Glutathione synthesis is a nutrient-dependent, stepwise process

An unbiased LC-MS-based metabolomic analysis of the small molecule metabolites in HNF4-positive HepG2 cells and HNF4-negative SNU449 cells, two widely used cell lines in the research community of liver cancer, revealed that SNU449 cells are significantly different from HepG2 cells in the abundance of 174 metabolites (Supplementary Table 1, p 1.5)

Fucoidan significantly inhibited depressive-like behavior and reduced BDNF mRNA expression in the hippocampus

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The series is active in vitro in the low nM range against 12 strains of P

In conclusion, our study found that vitamin B 12 insufficiency was associated with depressive disorders, while low vitamin B 12 levels were associated with SSD among child and adolescent psychiatric inpatients