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Mechanism of Action Cellular Redox Balance : Functions as the primary regulator of the reduced-to-oxidized glutathione ratio (GSH:GSSG) within cells, directly controlling the cellular environment that determines oxidative stress levels and metabolic efficiency

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Triplet combination of giredestrant, palbociclib, and GPX4 inhibition prevents clonal outgrowth even after short exposure to treatment The combination of CDK4/6 inhibition with endocrine therapies has been transformative for patients with ER+ breast cancer

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