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SIRT1 likely serves as a deacetylase for non-histone proteins, while HDAC13 are the major histone deacetylases in cells

4,7 The link between hearing loss and tinnitus has been suggested to be due to a compensatory effect: the brain compensates for decreased activation of the auditory nerve (which carries signals from the cochlea to the brain) by increasing gain or signal amplification in the auditory system of the brain, as well as decreasing auditory signal inhibition, which may result in tinnitus and possibly hypersensitivity to noise

doi: 10.3389/fimmu.2018.02061 162 LevringT

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In contrast, our design, by introducing a negative feedback loop, enabled bacterial cells to defend against synthetic nanostructures

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