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2022;40(16_suppl):25242524

It also appears to influence cell proliferation and modulate inflammation, with different molecular weights, such as LMW and HMW, exhibiting distinct biological activities

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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)