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Actin-binding and cell-migration activity of Thymosin Beta-4 (TB-500) in wound-healing research models

The in vitro data demonstrated that AOD9604 increases 3-AR expression in fat cells, contributing to enhanced lipolytic sensitivity

The resulting death of pericytes leaves the microvasculature continuously constricted, leading to microcirculatory failure and long-term cerebral hypoperfusion due to the contractile apparatus remaining in rigor upon pericyte death, thus reducing capillary diameter [94, 104]