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FOXO4-DRI interrupts the interaction between FOXO4 and p53, destabilizing the survival mechanisms of senescent cells

Large, well-designed Phase II/III RCTs with distinct primary goals, uniform diagnostic criteria, and active comparators are needed

Due to its critical role in these cellular processes, declining levels of NAD + are associated with general aging and chronic disorders, including cognitive decline, sarcopenia, and metabolic diseases

Cost efficiency: Cuts treatment expenses by 20 - 30% in high-income countries through optimized drug utilization (7)

10.1093/gerona/61.4.388 J

THF plays an important role in DNA synthesis, so reduced availability of THF results in ineffective production of cells with rapid turnover, in particular red blood cells, and also intestinal wall cells which are responsible for absorption