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Strikingly, in the active structure of the c-MET/HGF dimeric complex, only HGF I simultaneously recruits two c-METs by using two distinct surfaces localized on the opposite sides of this HGF (Fig

As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells

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High Dose (10 mcg/kg): Typically reserved for acute/severe injuries or advanced orthopedic conditions

HGF neurotrophic factor HGF and c-Met are actively expressed in both the developing and adult brains and nerves