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In the subsequent SURE-PD3 clinical trial, 298 individuals with early-onset PD were randomly assigned to receive placebo or oral inosine [106]

The ERGIC can then serve as a membrane source for LC3 lipidation, which is dependent on the adaptor protein WIPI2 and ATG5 but does not require ULK1 or VPS34, indicating that this non-canonical STING-dependent induction of autophagy can skip early steps of the canonical autophagy mechanism (158) ( Figure 4 )

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